Glucokinase vs. Other Hexokinases: Glucokinase is unique from other hexokinase in kinetic properties and is coded by a different gene. It is also allosterically inhibited by physiological concentrations of its immediate product, glucose-6-phosphate. 8.↑ Aleshin A, Malfois M, Liu X, Kim C, Fromm H, Honzatko R, Koch M, Svergun D. Nonaggregating Mutant of Recombinant Human Hexokinase I Exhibits Wild-Type Kinetics and Rod-like Conformations in Solution. 2003;206:2049–2057. Please enable it to take advantage of the complete set of features! Glucokinase (hexokinase D) is a monomeric cytoplasmic enzyme found in the liver and pancreas that serves to regulate glucose levels in these organs. The switch in conformations between the active form and the intermediate is a kinetically faster step than the change between the intermediate and the inactive form. The extraordinary specificity of Type II restriction endonucleases is believed to arise primarily from large conformational changes in enzyme and/or enzyme-bound DNA upon target-sequence recognition. Each domain weighs about 50kD and contains a jmolSetTarget('1');jmolLink('delete $clickGreenLinkEcho; refresh;set echo off; set echo wait4scene 50% 50%;set echo wait4scene center;font echo 24 serif plain;color $wait4scene [xffa500];background echo white;echo Loading, please wait ...;set echo dummy;background echo none;refresh; script /wiki/extensions/Proteopedia/spt/wipeFullLoadButton.spt; script /wiki/scripts/Bawel_sandbox1/Glucose_binding_site/1.spt;delete $wait4scene; ','glucose binding site','glucose binding site');. This is referred to as allosteric feedback inhibition because binding of product at one site affects the activity of the enzyme at a completely different site. Prior to glucose binding, hexokinase is said to be in the open configuration. Hexokinase deficiency appears to be inherited as an autosomal recessive disorder. Once glucokinase is in the active form, the enzymatic reaction is carried out with the presence of ATP. This page has been accessed 43,857 times. doi: 10.1038/ncpgasthep1357. Hexokinase Structure: The tertiary structure of hexokinase includes an jmolSetTarget('1');jmolLink('delete $clickGreenLinkEcho; refresh;set echo off; set echo wait4scene 50% 50%;set echo wait4scene center;font echo 24 serif plain;color $wait4scene [xffa500];background echo white;echo Loading, please wait ...;set echo dummy;background echo none;refresh; script /wiki/extensions/Proteopedia/spt/wipeFullLoadButton.spt; script /wiki/scripts/Kyle_Schroering_Sandbox/Secondary_structure/1.spt;delete $wait4scene; ','open alpha/beta sheet','open alpha/beta sheet');. Hepatic HK2 deletion inhibits tumor incidence in a mouse model of hepatocarcinogenesis. Glucokinase can be modulated to form an inactive and active complex. This gene encodes hexokinase 3. To elucidate the connection between the mechanics and the chemistry of DNA recognition and/or cleavage, van den Broek, Noom and Wuite (2005) used a single-molecule approach (see Chapter 12 for a description of laser optical trapping methods) to measure rate changes in the reaction pathway of EcoRV and BamHI as a function of DNA tension. The alternative is when the alpha 13 helix is modulated to form a smaller space thus activating the protein[4].
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